On Azelaic Acid and Metronidazole
On the Treatment of Skin Diseases, Azelaic Acid and Metronidazole are both important to physicians. Azelaic acid, a natural dibasic acid, is also effective in treating acne vulgaris, rosacea and other diseases. Its mild nature can not only inhibit the reproduction of Propionibacterium acne, but also reduce excessive keratosis of the hair follicle, and can also improve the appearance of skin pigmentation and make the skin uniform.

Metronidazole, also a commonly used medicine in dermatology, is especially good at anti-anaerobic bacteria. It is quite effective in the treatment of inflammatory papules and pustules in rosacea. Its mechanism of action is to interfere with the metabolism of bacteria, causing their death, and thus eliminating the inflammation of the skin.

However, compared with the two, azelaic acid has a slightly wider range of application. In addition to acne and rosacea, it also has an auxiliary function in pigmented skin diseases such as melasma. And its irritation is less, and those with sensitive skin can tolerate it. Although metronidazole has strong antibacterial power, some patients may have adverse reactions to local irritation, such as skin burning, itching, etc.

On the occasion of clinical syndrome, doctors should carefully observe the characteristics of the patient's skin and the severity of the disease, and choose it cautiously. If the patient's skin is sensitive and the disease is at the beginning, azelaic acid may be the preferred choice; if inflammation is significant and anaerobic bacteria are the main infection, metronidazole can be given priority. Both have their own strengths, and rational application can achieve the best therapeutic effect and relieve the pain of the patient's skin.