Azelaic acid and pregnancy-related matters

During pregnancy, the use of azelaic acid should be taken with caution, and the application of azelaic acid during pregnancy has also attracted much attention.

Azelaic acid has multiple effects such as antibacterial, anti-inflammatory and regulating keratinocyte differentiation. It is quite effective in the treatment of common skin problems. However, when a woman is pregnant with heavy weight, the safety of this drug becomes a key consideration.

Many studies have been dedicated to exploring the safety of azelaic acid during pregnancy. Some studies have shown that when azelaic acid is used externally, the amount absorbed through the skin is very small, and the amount of drug entering the systemic circulation is very small. In theory, it seems to have little effect on the fetus. However, there are also views that although no conclusive evidence of teratogenesis has been found so far, due to the special circumstances of pregnancy and changes in human physiology, it still needs to be treated with caution.

In practical clinical applications, if pregnant women suffer from acne and other diseases suitable for azelaic acid treatment, doctors will generally weigh the pros and cons comprehensively. If the disease is mild, non-drug therapies are preferred first, such as keeping the skin clean, adjusting diet and rest, etc. If the disease is serious and medication is really needed, other drugs with more sufficient safety evidence will also be given priority. If azelaic acid is not necessary, the doctor will inform the pregnant woman in detail of the potential risks and benefits, and use it in the smallest effective dose and shortest course of treatment after the pregnant woman fully informs and agrees, and closely monitor the condition of the pregnant woman and the fetus.

In conclusion, the use of azelaic acid during pregnancy, although controversial, should generally be based on the principle of ensuring the safety of pregnant women and fetuses, and drug decisions should be based on scientific basis and individual evaluation.