Effect of azelaic acid on cystic acne

Husband cystic acne, which is a more serious type of acne, often causes skin marks, affects the appearance, and plagues many patients. In recent years, azelaic acid has attracted more and more attention in the treatment of cystic acne.

Azelaic acid naturally exists in cereals, wheat and other plants. It has multiple pharmacological properties and is quite beneficial in the treatment of cystic acne.

First, azelaic acid has antibacterial properties. The pathogenesis of cystic acne is closely related to the proliferation of Propionibacterium acne. Azelaic acid can inhibit the growth and reproduction of the bacteria, and reduce the damage of bacteria to the hair follicles and surrounding tissues. Its mechanism of action is to inhibit the protein synthesis of bacteria, making it difficult for bacteria to survive and multiply.

Second, azelaic acid can regulate the differentiation of keratinocytes. Patients with cystic acne have excessive keratinization of the hair follicle mouth, resulting in poor sebum excretion, which in turn forms cysts. Azelaic acid can correct this abnormal keratinization process, so that the hair follicle mouth is unobstructed, sebum can be excreted normally, and the formation of cysts can be reduced.

Third, azelaic acid has anti-inflammatory effects. Local inflammation in cystic acne is significant, and azelaic acid can inhibit the release of inflammatory mediators It can reduce the chemotaxis of leukocytes, reduce the infiltration of inflammatory cells into tissues, and relieve symptoms such as redness, pain, etc.

Clinical application shows that the use of azelaic acid-containing preparations in the treatment of cystic acne has significantly improved the symptoms of some patients. Reduced skin redness, reduced number of cysts, and well tolerated, with fewer adverse reactions. Some patients only feel slight skin irritation in the early stage of treatment, such as itching and burning, but many can relieve themselves.

In short, azelaic acid has shown a good application prospect in the treatment of cystic acne. However, the therapeutic effect may vary depending on individual differences. In clinical application, it is appropriate to choose rationally according to the specific conditions of patients.